Publications
2022
Zhang, H. Y., De Biase, L., Chandra, R., Shen, H., Liu, Q. R., Gardner, E., Lobo, M. K., & Xi, Z. X. (2022). Repeated cocaine administration upregulates CB2 receptor expression in striatal medium-spiny neurons that express dopamine D1receptors in mice. Acta pharmacologica Sinica, 43(4), 876–888. https://doi.org/10.1038/s41401-021-00712-6
Franco, D., Wulff, A. B., Lobo, M. K., & Fox, M. E. (2022). Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice. Frontiers in behavioral neuroscience, 16, 821080. https://doi.org/10.3389/fnbeh.2022.821080
2021
Alipio, J., Haga, C., Fox, M. E., Arakawa, K., Balaji, R., Cramer, N., … Keller, A. (2021). Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior. Journal of Neuroscience. https://doi.org/10.1101/2020.09.19.304352
Calarco, C. A., Fox, M. E., Van Terheyden, S., Turner, M. D., Alipio, J. B., Chandra, R., & Lobo, M. K. (2021). Mitochondria-Related Nuclear Gene Expression in the Nucleus Accumbens and Blood Mitochondrial Copy Number After Developmental Fentanyl Exposure in Adolescent Male and Female C57BL/6 Mice. Frontiers in psychiatry, 12, 737389. https://doi.org/10.3389/fpsyt.2021.737389
Alipio, J. B., Haga, C., Fox, M. E., Arakawa, K., Balaji, R., Cramer, N., Lobo, M. K., & Keller, A. (2021). Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, JN-RM-2470-20. Advance online publication. https://doi.org/10.1523/JNEUROSCI.2470-20.2020
2020
Engeln, M*, Fox, ME*, Lobo, MK. (2020) Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress. Psychopharmacology Epub September 2020 *Denotes equal contribution
Fox, ME, Figueiredo, A*, Menken, MS*, Lobo, MK. (2020) Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat. Scientific Reports 10: 12393. *Denotes equal contribution
Engeln, M, Song, Y, Chandra, R, La, A, Fox, ME, Evans, B, Turner, MD, Thomas, S, Francis, TC, Hertzano, R, Lobo, MK. (2020) Individual differences in stereotypy and neuron subtype translatome with TrkB deletion. Molecular Psychiatry Epub May 2020.
Alipio, JB*, Brockett, AT*, Fox, ME, Tennyson, SS, deBettencourt, CA, El-Metwally, D, Francis, NA, Kanold, PO, Lobo, MK, Roesch, MR, Keller, A. (2020) Enduring consequences of perinatal fentanyl exposure in mice. Addiction Biology e12895. *Denotes equal contribution
2019
Engeln M, Mitra S, Chandra R, Gyawali U, Fox ME, Dietz DM, Lobo MK. (2019) Sex-specific role for Egr3 in nucleus accumbens D2-medium spiny neurons following long-term abstinence from cocaine self-administration. Biol Psychiatry. Epub Nov 2019
Chandra R, Calarco CA, Lobo MK. (2019) Differential mitochondrial morphology in ventral striatal projection neuron subtypes. J Neurosci Res. 97 (12): 1579-1589.
Fox ME, Lobo MK. (2019) The molecular and cellular mechanisms of depression: a focus on reward circuitry. Mol Psychiatry. Epub Apr 2019
Francis TC, Gaynor A, Chandra R, Fox ME, Lobo MK. (2019) The selective RhoA inhibitor Rhosin promotes stress resiliency through enhancing D1-medium spiny neuron plasticity and reducing hyperexcitability. Biol Psychiatry. 85: 1001-1010.
Liu S, Tang Y, Shu H, Tatum D, Bai Q, Crawford J, Xing Y, Lobo MK, Bellinger L, Kramer P, Tao F. (2019) Dopamine receptor D2, but not D1, mediates descending dopaminergic pathway-produced analgesic effect in a trigeminal neuropathic pain mouse model. Pain. 160:334-344.
2018
LeGates TA, Kvarta MD, Tooley JR, Francis TC, Lobo MK, Creed MC, Thompson SM. (2018) Reward behaviour is regulated by the strength of hippocampus-nucleus accumbens synapses. Nature. 564:258-262.
Divakaruni SS, Van Dyke AM, Chandra R, LeGates TA, Contreras M, Dharmasri PA, Higgs HN, Lobo MK, Thompson SM, Blanpied TA. (2018) Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction. Neuron. 100:860-875
Fox ME, Chandra R, Menken MS, Larkin EJ, Nam H, Engeln M, Francis TC, Lobo MK. Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior. Mol Psychiatry. Epub Aug 2018
Engeln M, Fox ME, Lobo MK. (2018) Dopamine Is Differentially Encoded by D2 Receptors in Striatal Subregions. Neuron. 98(3):459-461
Heshmati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan ME, Pfau ML, Hodes GE, Lepack AE, Bicks LK, Takahashi A, Chandra R, Turecki G, Lobo MK, Maze I, Golden SA, Russo SJ. Proc Natl Acad Sci U S A. Epub Jan 2018
Xu S, Zhu W, Wan Y, Wang J, Chen X, Pi L, Lobo MK, Ren B, Ying Z, Morris M, Cao Q. (2018) Decreased Taurine and Creatine in the Thalamus May Relate to Behavioral Impairments in Ethanol-Fed Mice: A Pilot Study of Proton Magnetic Resonance Spectroscopy. Mol Imaging. 17:1536012117749051
2017
Chandra R, Engeln M, Schiefer C, Patton MH, Martin JA, Werner CT, McGlincy M, Riggs L, Francis TC, Das S, Girven K, Konkolmatt P, Gancarz A, Golden SA, Iniguez S, Russo S, Turecki G, Mathur BN, Creed M, Dietz DM, Lobo MK. (2017) Mitochondrial fission in D1 neuron subtypes mediates cellular and behavioral plasticity during early cocaine abstinence. Neuron. 96:1327-41
Iñiguez SD, Flores-Ramirez FJ, Riggs LM, Alipio JB, Garcia-Carachure I, Hernandez MA, Sanchez DO, Lobo MK, Serrano PA, Braren SH, Castillo SA. (2017) Vicarious Social Defeat Stress Induces Depression-Related Outcomes in Female Mice. Biological Psychiatry. 83:9-17
Francis TC, Chandra R, Gaynor A, Konkalmatt P, Ransom Metzbower S, Blanpied TA, Lobo MK. (2017) Molecular basis of dendritic atrophy and activity in stress susceptibility. Molecular Psychiatry. 22:1512-19
Chandra R, Francis TC, Nam H, Riggs L, Engeln M, Rudzinskas S, Konkalmatt P, Russo S, Turecki G, Iniguez S, Lobo MK. (2017) Reduced Slc6a15 in nucleus accumbens D2-neurons underlies stress susceptibility. The Journal of Neuroscience. 37:6527-38.
Chandra R and Lobo MK. (2017) Beyond neuronal activity markers: select immediate early genes in striatal neuron subtypes functionally mediate psychostimulant addiction. Frontiers in Behavioral Neuroscience. 11:112
Lobo MK (2017) Nuclear Arc puts a break on cocaine-induced chromatin remodeling and behaviors. Biological Psychiatry. 81: 550-51
Engeln M and Lobo MK. (2017) Cocaine and striatal projection neuron subtype mechanisms. The neuroscience of cocaine: mechanisms and treatment. Elsevier Inc. Academic Press 297-306
Förstera B, Muñoz B, Lobo MK, Chandra R, Lovinger DM, Aguayo LG (2017) Presence of ethanol sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens. The Journal of Physiology. 10.1113
Castro A, Li Y, Raver C, Chandra R, Masri R, Lobo MK, Keller A. (2017) Neuropathic pain after chronic nerve constriction may not correlate with chloride dysregulation in mouse trigeminal nucleus caudalis neurons. PAIN. 158: 1366-72
Chandra R, Engeln M, Amgalan A, Fennel M, Chow A, Francis TC, Lobo MK. (2017) A Role for Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α in Nucleus Accumbens Neuron Subtypes in Cocaine Action. Biological Psychiatry. 81:564-72.
Francis TC and Lobo MK. (2017) Emerging role for nucleus accumbens medium spiny neuron subtypes in depression. Biological Psychiatry. 81:645-53
Terrillion CE, Francis TC, Puche AC, Lobo MK, Gould TD. (2017) Decreased nucleus accumbens expression of psychiatric disorder risk gene Cacna1c promotes susceptibility to social stress. Int J Neuropsychopharmacol. 20:428-33
Terrillion CE, Dao DT, Cachope R, Lobo MK, Puche AC, Cheer JF, Gould TD. (2017) Reduced levels of Cacna1c attenuate mesolimbic dopamine system function. Genes Brain Behav. 16: 495-505
2016
Damez-Werno D, Sun HS, Scobie K, Shao N, Rabkin J, Dias C, Calipari E, Maze I, Pena C, Walker D, Cahill M, Chandra R, Gancarz A, Mouzon R, Landry J, Cates H, Lobo MK, Dietz D, Allis CD, Guccione E, Turecki G, Defilippi P, Never RL, Hurd Y, Shen L, Nestler EJ. Histone Arginine Methylation in Cocaine Action: Essential Role of Src Signaling in the Nucleus Accumbens. PNAS. 113: 9623-8
Creed MC, Ntamati NR, Chandra R, Lobo MK, Luscher C. (2016) Convergence of reinforcing and anhedonic effects in the ventral pallidum. Neuron. 92: 214-226
2015
Wright KN, Hollis F, Duclot F, Dossat AM, Strong CE, Francis TC, Mercer R, Feng J, Dietz DM, Lobo MK, Nestler EJ, Kabbaj M. (2015) Methyl Supplementation Attenuates Cocaine-Seeking Behaviors and Cocaine-Induced c-Fos Activation in a DNA Methylation-Dependent Manner. J Neurosci. 35:8948-58
Kupchick YM, Brown RM, Heinsbroek JA, Lobo MK, Schwartz DJ, Kalivas PW. (2015) Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections. Nature Neurosci. 18:930-2
Chandra R, Francis TC, Konkalmatt P, Amgalan A, Gancarz AA, Dietz DM, Lobo MK. Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action. J Neurosci. 35:7927-7937 Link -.pdf
Francis TC, Chandra R, Friend DM, Finkel E, Dayrit G, Miranda J, Brooks JM, Iñiguez S, O’Donnell P, Kravitz A, Lobo MK. (2015) Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress. Biological Psychiatry. 77:212-222 Link -.pdf
Koo JW, Mazei-Robison MS, LaPlant Q, Egervari G, Braunscheidel KM, Adank DN, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno DM, Ribeiro E, Peña CJ, Walker D, Bagot RC, Cahill ME, Anderson SA, Labonté B, Hodes GE, Browne H, Chadwick B, Robison AJ, Vialou VF, Dias C, Lorsch Z, Mouzon E, Lobo MK, Dietz DM, Russo SJ, Neve RL, Hurd YL, Nestler EJ. (2015) Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nature Neurosci. Epub Feb 2015 Link
Ilango A and Lobo MK. (2015) Shining light on motivation, emotion and memory processes. Frontiers in Behav Neurosci. 9:1 Link -.pdf
Francis TC and Lobo MK. (2015) Optogenetic Regulation of Dopamine Receptor-Expressing Neurons. Neuromethods. 96:329-42. Link
2014
Francis TC, Chaudhury D, Lobo MK. (2014) Optogenetics: Illuminating the neural basis of rodent behavior. Open Access Animal Physiology. 6:33-51. Link -.pdf
Zhang Y, Crofton EJ, Li D, Lobo MK, Fan X, Nestler EJ, Green TA. (2104) Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment. Front Behav Neurosci. 8:297 Link
Koo JW, Lobo MK, Chaudhury D, Labonté B, Friedman A, Heller E, Peña CJ, Han MH, Nestler EJ. (2014) Loss of BDNF Signaling in D1R Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition. Neuropsyschopharm. 39:2646-53 Link
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun HS, Turecki G, Neve RL, Hurd YL, Shen L, Han M-H, Schaefer A, Nestler EJ. (2014) G9a influences neuronal subtype specification in striatum. Nature Neurosci. 17:533-9 Link
Papachatzaki MM, Gaspari S, Koo JW, Tsimpanouli ME, Stergiou E, Bagot RC, Ferguson D, Mouzon E, Chacravarty S, Deisseroth K, Lobo MK, Zachariou V. (2014) Nucleus Accumbens specific interventions in RGS9-2 activity modulate responses to morphine. Neuropsychopharm. Epub Feb 24 Link
Iñiguez SD, Alcantara LF, Warren BL, Riggs LM, Parise EM, Vialou V, Wright KN, Dayrit G, Nieto SJ, Wilkinson MB, Lobo MK, Neve RL, Nestler EJ, Bolaños-Guzmán CA. (2014) Fluoxetine Exposure during Adolescence Alters Responses to Aversive Stimuli in Adulthood. J Neurosci. 34:1007-21. Link
2013
Lobo MK, Zaman S, Damez-Werno D, Koo JW, Bagot R, DiNieri J, Nugent A, Finkel E, Chaudhury D, Chandra R, Riberio E, Rabkin J, Mouzon E, Cachope R, Cheer J, Han M-H, Dietz DM, Self D, Hurd Y, Vialou V, Nestler EJ (2013). DeltaFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli. J Neurosci. 33:18381-95 Link -File
Volman S, Lammel S, Margolis EB, Kim Y, Richard JM, Roitman MF, Lobo MK. New Insights into the Specificity and Plasticity of Reward and Aversion Encoding in the Mesolimbic System. J Neurosci. 33:17569-76 Link
Lee B, Ma Y-Y, Huang YH, Wang X, Otaka M, Ishikawa M, Neumann PA, Graziane NM, Brown TE, Suska A, Guo C, Lobo MK, Sesack SR, Wolf ME, Nestler EJ, Shaham Y, Schlüter OM, Dong Y. (2013) Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nature Neurosci. 16:1644-61 Link
Chandra R, Lenz JD, Gancarz AM, Chaudhury D, Schroeder GL, Han, M-H, Cheer JF, Dietz DM, Lobo MK. Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine- mediated regulation of Tiam1. Frontiers in Molecular Neurosci. 6:13 Link -.pdf
Lenz JL and Lobo MK. Optogenetic insights into striatal function and behavior. Behavioural Brain Research. 255:44-54 Link -.pdf
Thanos PK, Robinson L, Nestler EJ, Kim R, Michaelides M, Lobo MK, Volkow ND. Mapping brain metabolic connectivity in awake rats with MicroPET and Optogenetic Stimulation. J Neurosci. 33:6343-9 Link
Mason BL, Lobo MK, Parada L, Lutter M. Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight. Obesity. 21:2372-6 Link
Smith RJ, Lobo MK, Spencer S, Kalivas P. (2013) Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways). Curr Opin Neurobiol. 23:546-553 Link
Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai H-C, Pomeranz L, Christoffel DJ, Nectow AJ, Mouzon E, Ekstrand M, Domingos A, Mazei-Robison M, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han M-H. (2013) Phasic firing of ventral tegmental area dopamine neurons promotes rapid induction of depression behaviours. Nature. 493:532-6 Link
2012
Dietz K, Liu J, DeLoyht JM, Pedre X, Kelkar D, Kaur J, Vialou V, Lobo MK, Dietz DM, Nestler EJ, Dupree J, Casaccia P. (2012) Social isolation modulates nuclear heterochromatin in oligodendrocytes of the adult prefrontal cortex and impairs myelination. Nature Neurosci. 15:1621-3 Link
Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han M-H, and Nestler EJ. (2012) BDNF is a Negative Modulator of Morphine Action. Science. 338:124-8 Link
Dietz DM, Sun H, Lobo MK, Gao V, Chadwick B, Koo JW, Mazei-Robison MS, Damez-Werno D, Maze I, Dietz KC, Ferguson D, Christoffel D, Ohnishi Y, Hodes G, Zheng Y, Neve RL, Russo SJ and Nestler EJ. (2012) Essential role for Rac1 in cocaine-induced structural plasticity of nucleus accumbens neurons. Nature Neurosci. 15:891-6 Link
Lobo MK, Nestler EJ, Covington III HE. (2012) Optogenetic advancements toward a neurobiology of depression. Biol Psychiatry. 71:1068-74 Link -.pdf
Lobo MK. (2012) Lighting up the brain’s reward pathways. Ann N Y Acad Sci. 1260:24-33 Link
2011
Gutierrez R, Lobo MK, Zhang F, de Lecea L. (2011) Neural integration of reward, arousal, and feeding: Recruitment of VTA, lateral hypothalamus, and ventral striatal neurons. IUBMB Life. 10:824-30 Link
Covington HE 3rd, Maze I, Sun H, Bomze HM, Demaio KD, Wu EY, Dietz DM, Lobo MK, Ghose S, Mouzon E, Neve RL, Tamminga CA, Nestler EJ. (2011) A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron. 71:656-70 Link
Lobo MK and Nestler EJ (2011) The Striatal Balancing Act in Drug Addiction: Distinct Roles of Direct and Indirect Pathway Medium Spiny Neurons. Frontiers in Neuroanatomy. 5:1-11 Link
Wilkinson M, Dias C, Magida J, Mazei-Robison M, Lobo MK, Kennedy P, Dietz D, Covington III HE, Russo S, Neve R, Ghose S, Tamminga C, and Nestler EJ. (2011) A novel role for the protein dishevelled in the mouse nucleus accumbens in a social defeat model of depression. J Neurosci. 31:9084-92 Link
2010
Covington III HE, Lobo MK, Vialou V, Maze I, Hyman J, LaPlant Q, Mouzon E, Ghose S, Tamminga C, Neve R, Deisseroth K, Nestler EJ. (2010) Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci. 30:16082-09 Link
Lobo MK, Covington III HE, Chaudhury D, Friedman A.K., Sun H, Damez-Werno D, Dietz DM, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han M-H, Nestler EJ. (2010) Cell-type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science. 330: 385-390 Link -.pdf
Cao J-L, Vialou V, Lobo MK, Robison A, Neve RL, Cooper D, Nestler EJ, Han M-H. (2010) Essential Role of the cAMP-CREB Pathway in Opiate-Induced Homeostatic Adaptations of Locus Coeruleus Neurons. PNAS. 107: 17011-6 Link
2009
Lobo MK. (2009) Molecular profiling of striatonigral and striatopallidal medium spiny neurons past, present, and future. Int Rev Neurobiol. 89:1-35 Link
2008
Lobo MK, Yeh C, and Yang XW. (2008) Pivotal role of Ebf1 in development of striatonigral medium spiny neurons in the matrix compartment. J. Neurosci. Res. 86: 2134-2146 Link
2007
Lobo MK, Cui Y, Ostlund SB, Balleine BW and Yang XW. (2007) Genetic control of instrumental conditioning by striatopallidal neuron specific sphingosine-1-phosphate receptor Gpr6. Nature Neurosci. 11:1395-1397 Link -.pdf
2006
Hernandez-Echeagaray E, Cepeda C, Ariano MA, Lobo MK, Sibley DR, Levine, MS. (2006) Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D1 receptor subtype. Neurochem. Res. 32(2):229-40 Link
Lobo MK, Karsten SL, Gray M, Geschwind DH, Yang XW. (2006) FACS-Array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nature Neurosci. 9:443 – 452 Link -.pdf
2004
Andre VM, Flores-Hernandez J, Cepeda C, Starling AJ, Nguyen S, Lobo MK, Vinters HV, Levine MS, Mathern GW. (2004) NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. Cereb Cortex. 14:634-46 Link
2003
Lobo MK, Itri JN, Cepeda C, Chavira CA, Levine MS (2003) Ionotropic glutamate receptor expression and dopaminergic modulation in the developing sub thalamic nucleus of the rat: An immunohistochemical and electrophysiological analysis. Dev Neurosci. 25:384-93 Link
2000
Nansen EA, Jokel ES, Lobo MK, Micevych, PE, Ariano MA, Levine MS. (2000) Striatal ionotropic glutamate receptor ontogeny in the rat. Dev. Neurosci. 22:329-340. Link
Zhang, H. Y., De Biase, L., Chandra, R., Shen, H., Liu, Q. R., Gardner, E., Lobo, M. K., & Xi, Z. X. (2022). Repeated cocaine administration upregulates CB2 receptor expression in striatal medium-spiny neurons that express dopamine D1receptors in mice. Acta pharmacologica Sinica, 43(4), 876–888. https://doi.org/10.1038/s41401-021-00712-6
Franco, D., Wulff, A. B., Lobo, M. K., & Fox, M. E. (2022). Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice. Frontiers in behavioral neuroscience, 16, 821080. https://doi.org/10.3389/fnbeh.2022.821080
2021
Alipio, J., Haga, C., Fox, M. E., Arakawa, K., Balaji, R., Cramer, N., … Keller, A. (2021). Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior. Journal of Neuroscience. https://doi.org/10.1101/2020.09.19.304352
Calarco, C. A., Fox, M. E., Van Terheyden, S., Turner, M. D., Alipio, J. B., Chandra, R., & Lobo, M. K. (2021). Mitochondria-Related Nuclear Gene Expression in the Nucleus Accumbens and Blood Mitochondrial Copy Number After Developmental Fentanyl Exposure in Adolescent Male and Female C57BL/6 Mice. Frontiers in psychiatry, 12, 737389. https://doi.org/10.3389/fpsyt.2021.737389
Alipio, J. B., Haga, C., Fox, M. E., Arakawa, K., Balaji, R., Cramer, N., Lobo, M. K., & Keller, A. (2021). Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, JN-RM-2470-20. Advance online publication. https://doi.org/10.1523/JNEUROSCI.2470-20.2020
2020
Engeln, M*, Fox, ME*, Lobo, MK. (2020) Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress. Psychopharmacology Epub September 2020 *Denotes equal contribution
Fox, ME, Figueiredo, A*, Menken, MS*, Lobo, MK. (2020) Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat. Scientific Reports 10: 12393. *Denotes equal contribution
Engeln, M, Song, Y, Chandra, R, La, A, Fox, ME, Evans, B, Turner, MD, Thomas, S, Francis, TC, Hertzano, R, Lobo, MK. (2020) Individual differences in stereotypy and neuron subtype translatome with TrkB deletion. Molecular Psychiatry Epub May 2020.
Alipio, JB*, Brockett, AT*, Fox, ME, Tennyson, SS, deBettencourt, CA, El-Metwally, D, Francis, NA, Kanold, PO, Lobo, MK, Roesch, MR, Keller, A. (2020) Enduring consequences of perinatal fentanyl exposure in mice. Addiction Biology e12895. *Denotes equal contribution
2019
Engeln M, Mitra S, Chandra R, Gyawali U, Fox ME, Dietz DM, Lobo MK. (2019) Sex-specific role for Egr3 in nucleus accumbens D2-medium spiny neurons following long-term abstinence from cocaine self-administration. Biol Psychiatry. Epub Nov 2019
Chandra R, Calarco CA, Lobo MK. (2019) Differential mitochondrial morphology in ventral striatal projection neuron subtypes. J Neurosci Res. 97 (12): 1579-1589.
Fox ME, Lobo MK. (2019) The molecular and cellular mechanisms of depression: a focus on reward circuitry. Mol Psychiatry. Epub Apr 2019
Francis TC, Gaynor A, Chandra R, Fox ME, Lobo MK. (2019) The selective RhoA inhibitor Rhosin promotes stress resiliency through enhancing D1-medium spiny neuron plasticity and reducing hyperexcitability. Biol Psychiatry. 85: 1001-1010.
Liu S, Tang Y, Shu H, Tatum D, Bai Q, Crawford J, Xing Y, Lobo MK, Bellinger L, Kramer P, Tao F. (2019) Dopamine receptor D2, but not D1, mediates descending dopaminergic pathway-produced analgesic effect in a trigeminal neuropathic pain mouse model. Pain. 160:334-344.
2018
LeGates TA, Kvarta MD, Tooley JR, Francis TC, Lobo MK, Creed MC, Thompson SM. (2018) Reward behaviour is regulated by the strength of hippocampus-nucleus accumbens synapses. Nature. 564:258-262.
Divakaruni SS, Van Dyke AM, Chandra R, LeGates TA, Contreras M, Dharmasri PA, Higgs HN, Lobo MK, Thompson SM, Blanpied TA. (2018) Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction. Neuron. 100:860-875
Fox ME, Chandra R, Menken MS, Larkin EJ, Nam H, Engeln M, Francis TC, Lobo MK. Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior. Mol Psychiatry. Epub Aug 2018
Engeln M, Fox ME, Lobo MK. (2018) Dopamine Is Differentially Encoded by D2 Receptors in Striatal Subregions. Neuron. 98(3):459-461
Heshmati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan ME, Pfau ML, Hodes GE, Lepack AE, Bicks LK, Takahashi A, Chandra R, Turecki G, Lobo MK, Maze I, Golden SA, Russo SJ. Proc Natl Acad Sci U S A. Epub Jan 2018
Xu S, Zhu W, Wan Y, Wang J, Chen X, Pi L, Lobo MK, Ren B, Ying Z, Morris M, Cao Q. (2018) Decreased Taurine and Creatine in the Thalamus May Relate to Behavioral Impairments in Ethanol-Fed Mice: A Pilot Study of Proton Magnetic Resonance Spectroscopy. Mol Imaging. 17:1536012117749051
2017
Chandra R, Engeln M, Schiefer C, Patton MH, Martin JA, Werner CT, McGlincy M, Riggs L, Francis TC, Das S, Girven K, Konkolmatt P, Gancarz A, Golden SA, Iniguez S, Russo S, Turecki G, Mathur BN, Creed M, Dietz DM, Lobo MK. (2017) Mitochondrial fission in D1 neuron subtypes mediates cellular and behavioral plasticity during early cocaine abstinence. Neuron. 96:1327-41
Iñiguez SD, Flores-Ramirez FJ, Riggs LM, Alipio JB, Garcia-Carachure I, Hernandez MA, Sanchez DO, Lobo MK, Serrano PA, Braren SH, Castillo SA. (2017) Vicarious Social Defeat Stress Induces Depression-Related Outcomes in Female Mice. Biological Psychiatry. 83:9-17
Francis TC, Chandra R, Gaynor A, Konkalmatt P, Ransom Metzbower S, Blanpied TA, Lobo MK. (2017) Molecular basis of dendritic atrophy and activity in stress susceptibility. Molecular Psychiatry. 22:1512-19
Chandra R, Francis TC, Nam H, Riggs L, Engeln M, Rudzinskas S, Konkalmatt P, Russo S, Turecki G, Iniguez S, Lobo MK. (2017) Reduced Slc6a15 in nucleus accumbens D2-neurons underlies stress susceptibility. The Journal of Neuroscience. 37:6527-38.
Chandra R and Lobo MK. (2017) Beyond neuronal activity markers: select immediate early genes in striatal neuron subtypes functionally mediate psychostimulant addiction. Frontiers in Behavioral Neuroscience. 11:112
Lobo MK (2017) Nuclear Arc puts a break on cocaine-induced chromatin remodeling and behaviors. Biological Psychiatry. 81: 550-51
Engeln M and Lobo MK. (2017) Cocaine and striatal projection neuron subtype mechanisms. The neuroscience of cocaine: mechanisms and treatment. Elsevier Inc. Academic Press 297-306
Förstera B, Muñoz B, Lobo MK, Chandra R, Lovinger DM, Aguayo LG (2017) Presence of ethanol sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens. The Journal of Physiology. 10.1113
Castro A, Li Y, Raver C, Chandra R, Masri R, Lobo MK, Keller A. (2017) Neuropathic pain after chronic nerve constriction may not correlate with chloride dysregulation in mouse trigeminal nucleus caudalis neurons. PAIN. 158: 1366-72
Chandra R, Engeln M, Amgalan A, Fennel M, Chow A, Francis TC, Lobo MK. (2017) A Role for Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α in Nucleus Accumbens Neuron Subtypes in Cocaine Action. Biological Psychiatry. 81:564-72.
Francis TC and Lobo MK. (2017) Emerging role for nucleus accumbens medium spiny neuron subtypes in depression. Biological Psychiatry. 81:645-53
Terrillion CE, Francis TC, Puche AC, Lobo MK, Gould TD. (2017) Decreased nucleus accumbens expression of psychiatric disorder risk gene Cacna1c promotes susceptibility to social stress. Int J Neuropsychopharmacol. 20:428-33
Terrillion CE, Dao DT, Cachope R, Lobo MK, Puche AC, Cheer JF, Gould TD. (2017) Reduced levels of Cacna1c attenuate mesolimbic dopamine system function. Genes Brain Behav. 16: 495-505
2016
Damez-Werno D, Sun HS, Scobie K, Shao N, Rabkin J, Dias C, Calipari E, Maze I, Pena C, Walker D, Cahill M, Chandra R, Gancarz A, Mouzon R, Landry J, Cates H, Lobo MK, Dietz D, Allis CD, Guccione E, Turecki G, Defilippi P, Never RL, Hurd Y, Shen L, Nestler EJ. Histone Arginine Methylation in Cocaine Action: Essential Role of Src Signaling in the Nucleus Accumbens. PNAS. 113: 9623-8
Creed MC, Ntamati NR, Chandra R, Lobo MK, Luscher C. (2016) Convergence of reinforcing and anhedonic effects in the ventral pallidum. Neuron. 92: 214-226
2015
Wright KN, Hollis F, Duclot F, Dossat AM, Strong CE, Francis TC, Mercer R, Feng J, Dietz DM, Lobo MK, Nestler EJ, Kabbaj M. (2015) Methyl Supplementation Attenuates Cocaine-Seeking Behaviors and Cocaine-Induced c-Fos Activation in a DNA Methylation-Dependent Manner. J Neurosci. 35:8948-58
Kupchick YM, Brown RM, Heinsbroek JA, Lobo MK, Schwartz DJ, Kalivas PW. (2015) Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections. Nature Neurosci. 18:930-2
Chandra R, Francis TC, Konkalmatt P, Amgalan A, Gancarz AA, Dietz DM, Lobo MK. Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action. J Neurosci. 35:7927-7937 Link -.pdf
Francis TC, Chandra R, Friend DM, Finkel E, Dayrit G, Miranda J, Brooks JM, Iñiguez S, O’Donnell P, Kravitz A, Lobo MK. (2015) Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress. Biological Psychiatry. 77:212-222 Link -.pdf
Koo JW, Mazei-Robison MS, LaPlant Q, Egervari G, Braunscheidel KM, Adank DN, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno DM, Ribeiro E, Peña CJ, Walker D, Bagot RC, Cahill ME, Anderson SA, Labonté B, Hodes GE, Browne H, Chadwick B, Robison AJ, Vialou VF, Dias C, Lorsch Z, Mouzon E, Lobo MK, Dietz DM, Russo SJ, Neve RL, Hurd YL, Nestler EJ. (2015) Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nature Neurosci. Epub Feb 2015 Link
Ilango A and Lobo MK. (2015) Shining light on motivation, emotion and memory processes. Frontiers in Behav Neurosci. 9:1 Link -.pdf
Francis TC and Lobo MK. (2015) Optogenetic Regulation of Dopamine Receptor-Expressing Neurons. Neuromethods. 96:329-42. Link
2014
Francis TC, Chaudhury D, Lobo MK. (2014) Optogenetics: Illuminating the neural basis of rodent behavior. Open Access Animal Physiology. 6:33-51. Link -.pdf
Zhang Y, Crofton EJ, Li D, Lobo MK, Fan X, Nestler EJ, Green TA. (2104) Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment. Front Behav Neurosci. 8:297 Link
Koo JW, Lobo MK, Chaudhury D, Labonté B, Friedman A, Heller E, Peña CJ, Han MH, Nestler EJ. (2014) Loss of BDNF Signaling in D1R Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition. Neuropsyschopharm. 39:2646-53 Link
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun HS, Turecki G, Neve RL, Hurd YL, Shen L, Han M-H, Schaefer A, Nestler EJ. (2014) G9a influences neuronal subtype specification in striatum. Nature Neurosci. 17:533-9 Link
Papachatzaki MM, Gaspari S, Koo JW, Tsimpanouli ME, Stergiou E, Bagot RC, Ferguson D, Mouzon E, Chacravarty S, Deisseroth K, Lobo MK, Zachariou V. (2014) Nucleus Accumbens specific interventions in RGS9-2 activity modulate responses to morphine. Neuropsychopharm. Epub Feb 24 Link
Iñiguez SD, Alcantara LF, Warren BL, Riggs LM, Parise EM, Vialou V, Wright KN, Dayrit G, Nieto SJ, Wilkinson MB, Lobo MK, Neve RL, Nestler EJ, Bolaños-Guzmán CA. (2014) Fluoxetine Exposure during Adolescence Alters Responses to Aversive Stimuli in Adulthood. J Neurosci. 34:1007-21. Link
2013
Lobo MK, Zaman S, Damez-Werno D, Koo JW, Bagot R, DiNieri J, Nugent A, Finkel E, Chaudhury D, Chandra R, Riberio E, Rabkin J, Mouzon E, Cachope R, Cheer J, Han M-H, Dietz DM, Self D, Hurd Y, Vialou V, Nestler EJ (2013). DeltaFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli. J Neurosci. 33:18381-95 Link -File
Volman S, Lammel S, Margolis EB, Kim Y, Richard JM, Roitman MF, Lobo MK. New Insights into the Specificity and Plasticity of Reward and Aversion Encoding in the Mesolimbic System. J Neurosci. 33:17569-76 Link
Lee B, Ma Y-Y, Huang YH, Wang X, Otaka M, Ishikawa M, Neumann PA, Graziane NM, Brown TE, Suska A, Guo C, Lobo MK, Sesack SR, Wolf ME, Nestler EJ, Shaham Y, Schlüter OM, Dong Y. (2013) Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nature Neurosci. 16:1644-61 Link
Chandra R, Lenz JD, Gancarz AM, Chaudhury D, Schroeder GL, Han, M-H, Cheer JF, Dietz DM, Lobo MK. Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine- mediated regulation of Tiam1. Frontiers in Molecular Neurosci. 6:13 Link -.pdf
Lenz JL and Lobo MK. Optogenetic insights into striatal function and behavior. Behavioural Brain Research. 255:44-54 Link -.pdf
Thanos PK, Robinson L, Nestler EJ, Kim R, Michaelides M, Lobo MK, Volkow ND. Mapping brain metabolic connectivity in awake rats with MicroPET and Optogenetic Stimulation. J Neurosci. 33:6343-9 Link
Mason BL, Lobo MK, Parada L, Lutter M. Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight. Obesity. 21:2372-6 Link
Smith RJ, Lobo MK, Spencer S, Kalivas P. (2013) Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways). Curr Opin Neurobiol. 23:546-553 Link
Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai H-C, Pomeranz L, Christoffel DJ, Nectow AJ, Mouzon E, Ekstrand M, Domingos A, Mazei-Robison M, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han M-H. (2013) Phasic firing of ventral tegmental area dopamine neurons promotes rapid induction of depression behaviours. Nature. 493:532-6 Link
2012
Dietz K, Liu J, DeLoyht JM, Pedre X, Kelkar D, Kaur J, Vialou V, Lobo MK, Dietz DM, Nestler EJ, Dupree J, Casaccia P. (2012) Social isolation modulates nuclear heterochromatin in oligodendrocytes of the adult prefrontal cortex and impairs myelination. Nature Neurosci. 15:1621-3 Link
Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han M-H, and Nestler EJ. (2012) BDNF is a Negative Modulator of Morphine Action. Science. 338:124-8 Link
Dietz DM, Sun H, Lobo MK, Gao V, Chadwick B, Koo JW, Mazei-Robison MS, Damez-Werno D, Maze I, Dietz KC, Ferguson D, Christoffel D, Ohnishi Y, Hodes G, Zheng Y, Neve RL, Russo SJ and Nestler EJ. (2012) Essential role for Rac1 in cocaine-induced structural plasticity of nucleus accumbens neurons. Nature Neurosci. 15:891-6 Link
Lobo MK, Nestler EJ, Covington III HE. (2012) Optogenetic advancements toward a neurobiology of depression. Biol Psychiatry. 71:1068-74 Link -.pdf
Lobo MK. (2012) Lighting up the brain’s reward pathways. Ann N Y Acad Sci. 1260:24-33 Link
2011
Gutierrez R, Lobo MK, Zhang F, de Lecea L. (2011) Neural integration of reward, arousal, and feeding: Recruitment of VTA, lateral hypothalamus, and ventral striatal neurons. IUBMB Life. 10:824-30 Link
Covington HE 3rd, Maze I, Sun H, Bomze HM, Demaio KD, Wu EY, Dietz DM, Lobo MK, Ghose S, Mouzon E, Neve RL, Tamminga CA, Nestler EJ. (2011) A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron. 71:656-70 Link
Lobo MK and Nestler EJ (2011) The Striatal Balancing Act in Drug Addiction: Distinct Roles of Direct and Indirect Pathway Medium Spiny Neurons. Frontiers in Neuroanatomy. 5:1-11 Link
Wilkinson M, Dias C, Magida J, Mazei-Robison M, Lobo MK, Kennedy P, Dietz D, Covington III HE, Russo S, Neve R, Ghose S, Tamminga C, and Nestler EJ. (2011) A novel role for the protein dishevelled in the mouse nucleus accumbens in a social defeat model of depression. J Neurosci. 31:9084-92 Link
2010
Covington III HE, Lobo MK, Vialou V, Maze I, Hyman J, LaPlant Q, Mouzon E, Ghose S, Tamminga C, Neve R, Deisseroth K, Nestler EJ. (2010) Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci. 30:16082-09 Link
Lobo MK, Covington III HE, Chaudhury D, Friedman A.K., Sun H, Damez-Werno D, Dietz DM, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han M-H, Nestler EJ. (2010) Cell-type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science. 330: 385-390 Link -.pdf
Cao J-L, Vialou V, Lobo MK, Robison A, Neve RL, Cooper D, Nestler EJ, Han M-H. (2010) Essential Role of the cAMP-CREB Pathway in Opiate-Induced Homeostatic Adaptations of Locus Coeruleus Neurons. PNAS. 107: 17011-6 Link
2009
Lobo MK. (2009) Molecular profiling of striatonigral and striatopallidal medium spiny neurons past, present, and future. Int Rev Neurobiol. 89:1-35 Link
2008
Lobo MK, Yeh C, and Yang XW. (2008) Pivotal role of Ebf1 in development of striatonigral medium spiny neurons in the matrix compartment. J. Neurosci. Res. 86: 2134-2146 Link
2007
Lobo MK, Cui Y, Ostlund SB, Balleine BW and Yang XW. (2007) Genetic control of instrumental conditioning by striatopallidal neuron specific sphingosine-1-phosphate receptor Gpr6. Nature Neurosci. 11:1395-1397 Link -.pdf
2006
Hernandez-Echeagaray E, Cepeda C, Ariano MA, Lobo MK, Sibley DR, Levine, MS. (2006) Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D1 receptor subtype. Neurochem. Res. 32(2):229-40 Link
Lobo MK, Karsten SL, Gray M, Geschwind DH, Yang XW. (2006) FACS-Array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nature Neurosci. 9:443 – 452 Link -.pdf
2004
Andre VM, Flores-Hernandez J, Cepeda C, Starling AJ, Nguyen S, Lobo MK, Vinters HV, Levine MS, Mathern GW. (2004) NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. Cereb Cortex. 14:634-46 Link
2003
Lobo MK, Itri JN, Cepeda C, Chavira CA, Levine MS (2003) Ionotropic glutamate receptor expression and dopaminergic modulation in the developing sub thalamic nucleus of the rat: An immunohistochemical and electrophysiological analysis. Dev Neurosci. 25:384-93 Link
2000
Nansen EA, Jokel ES, Lobo MK, Micevych, PE, Ariano MA, Levine MS. (2000) Striatal ionotropic glutamate receptor ontogeny in the rat. Dev. Neurosci. 22:329-340. Link
